Kurt Gold, MD, Gabriela Garaycochea Neuroscience BS,
Greg Hirz, MD, Courtney Simmons, Neuroscience BS
Alzheimer’s disease is marked by, firstly the accumulation of plaques, specifically beta amyloid plaques, found in the open spaces around the cells, blocking cell-to-cell signallingin the synapses. Secondly, are the tau proteins. Tau protein replication in the brains of those who died alzheimer's are found to be misfolded and contorted with large amounts of phosphate groups attached to those areas hypersaturating which prevent normal tau functions, such as the stabilization and maintenance of microtubules, these are called neurofibrillary tangles when found in the cell bodies of the neurons. These mis-replicated tau proteins can also travel in the axons, known as neuriticplaque tau which compromise axonal transport and contribute to the synaptic degeneration.
Researchers are still not aware of the exact role microglia has in the mechanism of alzheimer's although it is understood they will alter their own function to better react to a strong immune response, at first, helping with the degradation of the beta amyloid plaques, however in the later stages, contributing to buildup of tau proteins as inflammation responses become too extreme. The astrocytes are also found attempting to help with the degradation of plaques.
1.Dancing and exercise, involving rhythms and pattern
2.Effective mind acuity practice, games!
3.Good diet of fresh fruits and vegetables such as berries.
4.Avoiding sugar products
5.Supplements such as turmeric, ginger, olive oil.
6.Sleeping sanctuary-harnessing the power of the Glymphatic system
7.Stress management